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Antihemophilic Factor (Recombinant)


Related terms
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    Related terms
    • Brand Names: U.S.: Advate;Helixate® FS;Kogenate® FS;Recombinate;Xyntha®;Xyntha® SolofuseT
    • Brand Names: Canada: Advate;Helixate® FS;Kogenate® FS;Xyntha®

    • It is used to treat hemophilia.
    • It is used to stop and treat bleeding.
    • Antihemophilic factor (recombinant) replaces proteins to stop bleeding.


    How to take

    • It is given as a shot into a vein.
    • This drug may be given at home.
    • Your doctor may teach you how to give the shot.
    • Wash your hands before and after use.
    • Throw away needles in a needle/sharp disposal box and take the box back to your doctor when it is full.


    • Most of the time, this drug will be given to you in a doctor's office. You will not store it at home.
    • If this drug is given at home, store unopened vials at room temperature or in the refrigerator. Do not freeze.
    • If stored at room temperature, throw away any unused Advate vials after 6 months.
    • If stored at room temperature, throw away any unused Helixate® FS or Xyntha® SolufuseT vials after 3 months.
    • If stored at room temperature, throw away any unused Kogenate® FS vials after 12 months.
    • If stored at room temperature, after 3 months return Xyntha® vials to the refrigerator or throw away any part unused. You may return vials to the refrigerator only 1 time.
    • Protect from light.



    • If you have an allergy to antihemophilic factor (recombinant), mice, hamsters, pigs, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Short-term pain after use.
    • Allergic side effects may rarely happen.
    • Blood clots, heart attacks, and other blood vessel problems may rarely happen.


    • Change in the health problem being treated. Is it better, worse, or about the same?
    • Follow up with the doctor.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Trouble breathing.
    • Chest pain or pressure.
    • Change in thinking clearly and with logic.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Weakness, numbness, or tingling.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.