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Chlorhexidine Gluconate


Related terms
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    Related terms
    • Brand Names: U.S.: AvagardT [OTC];Bactoshield® CHG [OTC];Betasept® [OTC];ChloraPrep® Frepp® [OTC];ChloraPrep® Sepp® [OTC];ChloraPrep® [OTC];ChlorascrubT Maxi [OTC];ChlorascrubT [OTC];Dyna-Hex® [OTC];Hibiclens® [OTC];Hibistat® [OTC];Operand® Chlorhexidine Gluconate [OTC];Peridex®;periochip®;PerioGard® [OTC]
    • Brand Names: Canada: Hibidil® 1:2000;ORO-Clense;Peridex® Oral Rinse

    • It is used to stop and treat mouth infections.
    • It is used to clean the skin.
    • Chlorhexidine gluconate works to harm the bacteria and fight the infection.


    How to take

    • Oral rinse:
    • Brush and floss your teeth.
    • Rinse with 1 tablespoon (15 mL) of this drug for 30 seconds.
    • Do not swallow this drug.
    • Rinse 2 times a day, in the morning and in the evening.
    • Wait 30 minutes before eating, drinking, using mouthwash, or brushing teeth.
    • Oral chip:
    • Your doctor will give this drug.
    • Do not floss close to where the chip was placed for 10 days.
    • Skin (cleanser):
    • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, ears, and eyes (may burn).
    • Skin (hand sanitizer):
    • Work under fingertips.
    • Spread over hand and to just above elbow.
    • Put 1 more pumpful on both hands and spread over hands and up to the wrists.
    • Rub into hands until dry.
    • Skin (hand washing):
    • Wet hands and forearms.
    • Put 1 teaspoon (5 mL) on hands and wash for 1 minute.
    • Rinse affected part with water. Make sure to it dry well.
    • Skin (before surgery):
    • Your doctor may teach you how to use.
    • Your doctor may put on the skin.
    • Skin (surgical wash):
    • Your doctor will give this drug.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Many times this drug is used on an as needed basis.


    • Store at room temperature.
    • Protect from heat.



    • If you have an allergy to chlorhexidine gluconate or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • All products:
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.
    • Oral:
    • If you have front-tooth fillings or gum problems, talk with your doctor.
    • Skin:
    • Protect clothing and fabrics from staining.

    Side Effects

    • Oral:
    • Mouth and lip irritation. Using a soft toothbrush or cotton swabs and rinsing the mouth may help. Do not use mouth rinses that have alcohol in them.
    • Bad taste in your mouth. This most often goes back to normal.
    • Skin:
    • Dryness.
    • Skin irritation.


    • Oral:
    • Change in the health problem being treated. Is it better, worse, or about the same?

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad skin irritation.
    • Any rash.
    • Oral:
    • Very bad gum pain or swelling.
    • Numbness or tingling in your mouth.
    • Staining of your mouth, teeth, or fillings.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.