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Related terms
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    Related terms
    • Brand Names: U.S.: Depo-Provera®;Depo-Provera® Contraceptive;depo-subQ provera 104®;Provera®
    • Brand Names: Canada: Alti-MPA;Apo-Medroxy®;Depo-Prevera®;Depo-Provera®;Dom-Medroxyprogesterone;Gen-Medroxy;Medroxy;Medroxyprogesterone Acetate Injectable Suspension USP;Novo-Medrone;PMS-Medroxyprogesterone;Provera-Pak;Provera®;Teva-Medroxyprogesterone

    • It is used to stop pregnancy.
    • It is used to stop endometrial changes in women after change of life who are getting estrogen therapy.
    • It is used to stop pain caused by endometriosis.
    • It is used to treat uterine bleeding due to hormonal imbalance.
    • It is used to treat endometrial cancer.
    • It is used to treat women who do not have a monthly period cycle.
    • Progestins are made by the body and are used by the milk-making glands and to help the period (menstrual) cycle.
    • Medroxyprogesterone stops egg growth and egg release (ovulation) to avoid pregnancy.


    How to take

    • Follow the diet and workout plan that your doctor told you about.
    • Oral:
    • Take tablet with or without food. Take with food if it causes an upset stomach.
    • Shot:
    • It is given as a shot into a muscle. Depo-subQ provera 104T is given as a shot into the fatty part of the skin.

    Missed Dose

    • Oral:
    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Shot:
    • Call your doctor to find out what to do.


    • Store tablets at room temperature.
    • Protect tablets from water. Do not store in a bathroom or kitchen.
    • The shot will be given to you in a hospital or doctor's office. You will not store it at home.



    • Do not take this drug during the first 4 months of your pregnancy. Progestins may cause birth defects. Call your doctor if you think you may be pregnant. This drug does not stop the spread of diseases caused by having sex.
    • Women taking this drug for birth control may lose bone. Bone loss is greater the longer the drug is used. It is not known what the effects will be on bones when used in teenage and young adult women.
    • Do not take estrogens to stop heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
    • This drug does not protect the body from HIV infection or other diseases caused by having sex.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.


    • If you have an allergy to medroxyprogesterone or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Blood clots, liver disease, stroke, or vaginal bleeding.
    • If you are pregnant or may be pregnant.


    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Avoid cigarette smoking.
    • If you have breast or any genital cancer, talk with your doctor.
    • If you have any blood flow problems, talk with your doctor.
    • Have your blood pressure checked often. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Do monthly breast self-exams and have a gynecologic exam every year.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Weight gain.
    • Weak bones with long-term use.
    • Headache.
    • Feeling tired or weak.
    • Belly pain.
    • More hungry.
    • Swelling.
    • Period (menstrual) changes. These include lots of bleeding, spotting, or bleeding between cycles.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure.
    • Trouble breathing.
    • Swelling, warmth, or pain in the leg or arm.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

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    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.