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Sumatriptan Succinate


Related terms
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    Related terms
    • Brand Names: U.S.: AlsumaT;Imitrex®;Sumavel® DosePro®
    • Brand Names: Canada: Apo-Sumatriptan®;Ava-Sumatriptan;CO Sumatriptan;Dom-Sumatriptan;Imitrex®;Imitrex® DF;Imitrex® Injection;Imitrex® Nasal Spray;Mylan-Sumatriptan;PHL-Sumatriptan;PMS-Sumatriptan;Riva-Sumatriptan;Sandoz-Sumatriptan;Sumatriptan Injection;Sumatriptan Sun Injection;Sumatryx;Teva-Sumatriptan;Teva-Sumatriptan DF

    • It is used to treat headaches.
    • Sumatriptan lowers swelling of blood vessels in the brain that cause the migraine.


    How to take

    • Keep a diary of your headaches.
    • Oral:
    • Swallow tablet whole. Do not chew, break, or crush.
    • Take with liquids as early as you can after the attack has started.
    • If your headache comes back after the first dose, 1 more dose may be taken 2 hours after the first one.
    • Shot:
    • The shot is given under the skin as early as it can be after the attack has started.
    • Your doctor will teach you how to give the shot.
    • If more than 1 shot is needed, space each shot by 1 hour.
    • Wash your hands before and after use.
    • Throw away needles in a needle/sharp disposal box and take the box back to your doctor when it is full.
    • Intranasal:
    • For the nose only.
    • Spray a single dose in 1 nostril as early as you can after the attack has started.
    • If the headache comes back, the dose may be repeated once after 2 hours.

    Missed Dose

    • This drug is taken on an as needed basis.


    • Store at room temperature.
    • Protect from light.
    • Protect tablets from water. Do not store in a bathroom or kitchen.



    • There is a chance of serotonin syndrome when using this drug with some drugs for low mood (depression) or weight loss. The syndrome is caused by too much serotonin in the body. Signs include agitation, changes in blood pressure, loose stools, a fast heartbeat, hallucinations, upset stomach and throwing up, change in balance, and change in thinking clearly and with logic. Talk with your doctor.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.


    • If you have an allergy to sumatriptan succinate or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Some types of migraine headaches, chest pain or pressure, diseased arteries going to the legs, heart attack, heart disease, very bad liver disease, poor bowel blood flow, stroke, or very high blood pressure.
    • If you are using this drug to stop you from getting migraine headaches.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
    • If you have taken almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, or zolmitriptan in the last 24 hours.
    • If you have taken ergotamine, methysergide, or dihydroergotamine in the last 24 hours.


    • If you have liver disease, talk with your doctor.
    • Use care if you have risks for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar (diabetes), cigarette smoking, man older than 40 years of age, other family members with early heart disease, woman after change of life). Talk with your doctor.
    • If you take this drug 10 or more days in a month your headaches may become worse.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Avoid beer, wine, or mixed drinks.
    • You may not be alert. Avoid driving and doing other tasks or actions until you see how this drug affects you.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • All products:
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loss of eyesight. This can be long-lasting.
    • Oral tablet/shot:
    • Flushing. Wearing layers of clothes or summer clothes and staying in cool places may help.
    • Skin irritation.
    • Intranasal:
    • Bad taste in your mouth. This most often goes back to normal.
    • Nose irritation.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure, a fast heartbeat, or passing out.
    • Change in thinking clearly and with logic.
    • Big change in balance.
    • Agitation, twitching, sweating, or muscle stiffness.
    • Very nervous and excitable.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Very bad headache or if headache is not better after the first dose.
    • Numbness or tingling in your hands or feet.
    • Sudden change in eyesight, eye pain, or irritation.
    • Very upset stomach or throwing up.
    • Very bad belly pain or bloody loose stools.
    • Feeling very tired or weak.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
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    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.